Cell Encapsulation
The Neovascularized Implantable Cell Homing and Encapsulation (NICHE) platform is a 3D-printed implant that enables a vascularized microenvironment which can support long-term cell engraftment along with local immune modulation. Leading clinical application is pancreatic beta cell therapy for T1D.
Cell Reprogramming
The NanoLymph is a 3D-printed platform that features two reservoirs; one chamber to facilitate cell recruitment and reprogramming in vivo and the other chamber to release immunomodulatory agents to initially recruit cells and then protect the cells during reprogramming. Leading clinical applications can be cancer vaccination and immune modulation therapies.
Intratumoral
The nanofluidic drug-eluting seed (NDES) is a small implant featuring a silicon nanofluidic membrane that can achieve sustained local drug delivery when implanted within solid tumors. Leading clinical applications are local chemotherapy and immunotherapy; with added benefit of minimizing systemic side effects.
Extended Delivery
The nanochannel drug delivery system (nDS) based on tunable silicon membrane technology is a refillable, long-term subcutaneous implant that provides continuous, sustained release of therapeutics for chronic disease treatment or prevention. Leading clinical application is pre-exposure prophylaxis (PrEP) and HIV treatment to enhance medication adherence for epidemic control.